|Record of activities in 2023 at KURCPI
Research Seminar No.226, 16 January 2023
16:30-, The Interdivisional Education and Research Building, 5th Floorbr
「Medicine and food - from Satsuma Kurozen to ninjin’yoeito research」
(Pharmacological Department of Herbal Medicine, Kagoshima University Graduate School of Medical & Dental Sciences)
The Kagoshima University Food and Health Project aims to contribute to healthy longevity, with special reference to the prevention of lifestyle-related diseases and frailty, a condition requiring a cane, through Kagoshima functional food, the same source as Kampo medicine.
One of the projects is Kurozen (Satsuma Kurozen bento), which incorporates black rice and black vegetables containing rich anthocyanins, won the Excellence Award (2nd place) in the bento category of the 2019 National Supermarket Association. Another is the shochu project, in which we have identified functional ingredients with anti-metabolic effects as well as ghrelin-like substances that work similarly to ghrelin, a hunger hormone secreted from the stomach, that can suppress aging and promotes healthy longevity. Based on these findings, we are now developing functional shochu.
Ninjin’yoeito is called the strongest Hozai in Kampo medicine, and it has been reported to show the preventive and therapeutic effects on frailty such as strengthening immune function, promoting appetite, and reducing sarcopenia in the elderly. This Kampo medicine acts to stimulate ghrelin and hypothalamic neuropeptide Y downstream thereof. This hunger system forms the basis of caloric restriction and is deeply involved in healthy longevity, tumor suppression, and stress tolerance.
Kampo medicines contain many kinds of herbal drugs. Chinpi, dried citrus peels, are components of a substantial number of Kampo medicine including ninjin’yoeito. One of the origins of chinpi is Sakurajima small tangerine that also contains a lot of active ingredients such as hesperidin which stimulate ghrelin secretion. In this lecture, I will discuss the progress of modern medicine in healthy longevity from the standpoint of the same source of medicine and food.